Phosphine-Triggered Complete Chemo-Switch: From Efficient Aldehyde−Alkyne−Amine Coupling to Efficient Aldehyde−Alkyne Coupling in Water
Organic Letters2005Vol. 7(20), pp. 4395–4398
Citations Over TimeTop 10% of 2005 papers
Abstract
[reaction: see text] A phosphine ligand served as a remarkable chemo-switch for the silver-catalyzed reaction of alkynes with aldehydes in the presence of amines in water. Exclusive aldehyde-alkyne-amine coupling product was observed in the absence of phosphine, whereas in the presence of a phosphine ligand, exclusive aldehyde-alkyne coupling product was obtained.
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