Aminolysis of Resin-Bound N-Nosylaziridine-2-carboxylic Acids
Organic Letters2006Vol. 8(15), pp. 3371–3374
Citations Over TimeTop 12% of 2006 papers
Christian A. Olsen, Caspar Christensen, Birgitte Nielsen, Mohamed M. Farah, Matthias Witt, Rasmus P. Clausen, Jesper L. Kristensen, Henrik Franzyk, Jerzy W. Jaroszewski
Abstract
[Structure: see text] Solid-phase synthesis is a rapidly developing area of organic chemistry, of particular importance for medicinal chemistry and chemical biology. Aziridines have previously only rarely been applied in solid-phase synthesis. In the present work, aminolysis of resin-bound, spring-loaded N-nitrobenzenesulfonyl-activated aziridine-2-carboxylic acids has been optimized and employed in the synthesis of a number of open-chain and heterocyclic scaffolds, including enantiopure products.
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