Asymmetric Total Synthesis of Nigerone
Organic Letters2007Vol. 9(3), pp. 385–388
Citations Over TimeTop 10% of 2007 papers
Abstract
[reaction: see text] An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative biaryl coupling of an advanced intermediate with a 1,5-diaza-cis-decalin copper catalyst.
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