Efficient Nucleophilic Aromatic Substitution between Aryl Nitrofluorides and Alkynes
Organic Letters2007Vol. 9(14), pp. 2741–2743
Citations Over TimeTop 20% of 2007 papers
Abstract
The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions.
Related Papers
- → A New Leaving Group in Nucleophilic Aromatic Substitution Reactions (SNAr)(2008)9 cited
- → Electrochemically induced aromatic substitution. The 2-nitropropane anion, a powerful nucleophile in SRN1 aromatic substitution(1986)20 cited
- → Aromatic nucleophilic substitution. 27. Aromatic nucleophilic substitution reactions of 1-(alkylamino)-2,4-dinitronaphthalenes with various primary amines in dimethyl sulfoxide(1990)11 cited
- → Photoinduced Aromatic Nucleophilic Substitution Reactions(2004)4 cited
- The Electrophilic Aromatic Addition and Substitution Reactions of Metallabenzenes(2011)