Regioselective Cobalt-Catalyzed Formation of Bicyclic 3- and 4-Aminopyridines
Organic Letters2011Vol. 13(8), pp. 2030–2033
Citations Over TimeTop 10% of 2011 papers
Pierre Garcia, Yannick Evanno, Pascal George, Mireille Sevrin, Gino Ricci, Max Malacrìa, Corinne Aubert, Vincent Gandon
Abstract
Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.
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