Enantioselective Synthesis of α-Stereogenic γ-Keto Esters via Formal Umpolung
Organic Letters2012Vol. 14(13), pp. 3260–3263
Citations Over TimeTop 16% of 2012 papers
Abstract
A feasible method has been developed for the enantioselective synthesis of α-stereogenic γ-keto esters. By employing nitro(phenylsulfonyl)methane as an acyl anion equivalent, the integrated Michael addition reaction-oxidative methanolysis protocol allows the preparation of various γ-keto esters with high optical purities.
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