Copper-Catalyzed Enantioselective IntramolecularN-Arylation, an Efficient Method for Kinetic Resolutions
Organic Letters2013Vol. 15(14), pp. 3598–3601
Citations Over TimeTop 10% of 2013 papers
Abstract
For the first time, copper-catalyzed intramolecular N-arylation was successfully applied to the kinetic resolution strategy. Under the catalysis of CuI-BINOL derived ligands, the kinetic resolution of rac-2-amino-3-(2-iodoaryl)propionates and rac-2-amino-4-(2-iodoaryl)butanoates afforded chiral intramolecular coupling products and recovered the starting materials in high enantioselectivity (s factors up to 245).
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