Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)–H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes
Organic Letters2013Vol. 15(24), pp. 6202–6205
Citations Over TimeTop 10% of 2013 papers
Abstract
Pd(II)-catalyzed tertiary C(sp(3))-H arylation of cyclopropanes via directing group-mediated C-H activation for the construction of a chiral quaternary carbon center on cyclopropanes using aryl iodides as a coupling partner is reported. The arylation had a wide substrate scope and good functional group tolerance, including heteroaryl iodides, to provide various chiral arylcyclopropanes with the cis- and trans-1,1,2-trisubstituted structures.
Related Papers
- → Recent Advances in the Enantioselective Synthesis of β-Amino Acids(1999)190 cited
- → Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids(2006)145 cited
- → Electrochemical Tandem Cyclization of Unsaturated Oximes with Diselenides: A General Approach to Seleno Isoxazolines Derivatives with Quaternary Carbon Center(2021)28 cited
- → Diastereoselective and enantioselective synthesis of 1,2-disubstituted cycloalkanecarboxaldehydes(1981)53 cited
- → Enantioselective Synthesis of (−)-Dendroprimine and Isomers(2004)11 cited