Fam−Ti Catalyzed Enantioselective Alkynylation of Aldehydes
Organic Letters2007Vol. 9(17), pp. 3477–3479
Citations Over TimeTop 10% of 2007 papers
Abstract
Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.
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