A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by Multicomponent Reaction Cascades
Organic Letters2007Vol. 9(24), pp. 5035–5038
Citations Over TimeTop 10% of 2007 papers
Abstract
Small molecule diversity can be achieved in a single synthetic operation from bifunctional substrates in the absence of additives and under the influence of microwaves with complete control of pathway selectivity. The preliminary Ugi four-component coupling products give rise to three structurally distinct scaffolds that are dependent on solvent effects and sterics. 2,5-Diketopiperazines (Type A), 2-azaspiro[4.5]deca-6,9-diene-3,8-diones (Type B), and thiophene-derived Diels-Alder tricyclic lactams (Type C) predominate in this reaction cascade.
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