Base-Catalyzed Intramolecular Hydroamination of Conjugated Enynes
Organic Letters2008Vol. 10(10), pp. 2023–2026
Citations Over TimeTop 10% of 2008 papers
Abstract
A de novo intramolecular hydroamination of conjugated enynes was developed using commercially available n-BuLi as a precatalyst. This hydroamination reaction successfully afforded allenyl-substituted pyrrolidines with up to 95% yield. One of the resulting allenyl pyrrolidines was converted to the natural products irniine and irnidine in three steps.
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