Synthesis of Benzoxazolones from Nitroarenes or Aryl Halides
Organic Letters2010Vol. 12(4), pp. 812–815
Citations Over TimeTop 21% of 2010 papers
Abstract
A simple and effective method for the preparation of benzoxazolones from nitroarenes or aryl halides is described. Partial reduction of a nitro group in the presence of a chloroformate followed by a microwave-assisted rearrangement/ring closure sequence provides a convenient and practical procedure to prepare this important pharmacophore. Rearrangement precursors were also accessed from aryl halides through transition-metal-catalyzed coupling.
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