Enantioselective Synthesis of (−)-LL-C10037α from Benzoquinone
Organic Letters1999Vol. 1(9), pp. 1483–1485
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Abstract
The enantioselective total synthesis of the Streptomyces metabolite (−)-LL-C10037α has been accomplished in 10 steps and 20% overall yield. An early chiral intermediate was resolved with Candida rugosa lipase to provide (+)-5 with an enantiomeric excess ≥98%. The synthesis is notable in that no protecting groups are required and that all carbons in the core structure of LL-C10037α are derived from the readily available p-benzoquinone.
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