Chiral Dirhodium(II) Catalysts with Ortho-Metalated Arylphosphine Ligands: Synthesis and Application to the Enantioselective Cyclopropanation of α-Diazo Ketones

Citations Over TimeTop 10% of 2002 papers

Abstract

Chiral dirhodium(II) compounds, Rh2(O2CR)2(pc)2 (pc = ortho-metalated arylphosphine), with a head-to-tail arrangement (1−21) are used in the cyclopropanation of α-diazo ketones. The influence of catalyst ligands and substrate structure on enantioselectivity is studied. Temperature and solvent dependence assays are performed, the best ee values being obtained in refluxing pentane. Results compare favorably with those reported in the literature using Ru, Cu, and other Rh(II) catalysts.

Related Papers

• → Cyclopropanation Reactions of Semi-stabilized and Non-stabilized Diazo Compounds(2019)45 cited
• → An enantioselective approach to (−)-platencin via catalytic asymmetric intramolecular cyclopropanation(2010)36 cited
• → Chiral Dirhodium(II) Catalysts with Ortho-Metalated Arylphosphine Ligands: Synthesis and Application to the Enantioselective Cyclopropanation of α-Diazo Ketones(2002)55 cited
• → Cyclopropanation of β,γ-Unsaturated α-Keto Esters with Diazo Esters(2017)
• → ChemInform Abstract: α‐Diazo‐β‐ketonitriles: Uniquely Reactive Substrates for Arene and Alkene Cyclopropanation.(2013)