Carbon−Carbon Bond Formation through Double sp2 C−H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives

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Abstract

Direct arylation of simple arenes with ferrocenyl oxazolines was achieved in the presence of a stoichiometric amount of Pd(OAc)2 or a catalytic amount of palladium with excess oxidant such as Cu(OAc)2. This double sp2 C−H activation process provides a unique access to the aryl-substituted ferrocene derivatives, even in the enantiopure form of planar chirality, in a few steps from readily available starting materials.

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