Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale
Organic Process Research & Development2011Vol. 15(4), pp. 783–787
Citations Over TimeTop 10% of 2011 papers
Abstract
A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 μL microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour .
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