Convergent Asymmetric Synthesis of Two Complex TRPV1 Antagonists
Organic Process Research & Development2011Vol. 15(5), pp. 1192–1200
Citations Over TimeTop 15% of 2011 papers
Kenneth J. Butcher, Steven M. Denton, Stuart Field, Adam T. Gillmore, Gareth W. Harbottle, Roger M. Howard, Daniel A. Laity, Christian J. Ngono, Benjamin A. Pibworth
Abstract
The convergent scale-up synthesis of two complex TRPV1 antagonists to support exploratory toxicology studies is described. Both compounds contain three chiral centers introduced by asymmetric synthesis with chiral control being critical for the success of the project. Preparation of the key cyclopropyl intermediate utilised an asymmetric cyclopropanation using thermally unstable ethyl diazoacetate. Ellman’s auxiliary was used to synthesize the chiral α-methyl benzylamine fragments. This paper highlights some of the key synthetic challenges, processing issues, and safety aspects from the scale-up of this chemistry.
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