Chemical Development of NBI-75043. Use of a Flow Reactor to Circumvent a Batch-Limited Metal−Halogen Exchange Reaction
Organic Process Research & Development2008Vol. 12(5), pp. 929–939
Citations Over TimeTop 14% of 2008 papers
Timothy D. Gross, Shine Chou, Daniel Bonneville, Raymond S. Gross, Peng Wang, Onorato Campopiano, Michael A. Ouellette, Scott E. Zook, Jayachandra P. Reddy, Wilna J. Moree, Florence Jovic, Shubham P. Chopade
Abstract
The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.
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