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The DNA sequence and comparative analysis of human chromosome 20

Nature2001Vol. 414(6866), pp. 865–871

Citations Over TimeTop 1% of 2001 papers

J.H. Burton, N. Corby, Melissa J. Moore, Siobhan Whitehead, Adam P. Butler, Sarah Hunt, Richard Durbin, Matt Jones, S. M. Clegg, R. E. Collier, Andrew Knights, T Nickerson, Christine Bird, G. J. Coville, R. Shownkeen, M. T. Ross, Mark D. Vaudin, John Sulston, Rajni V. Patel, Philip Howden, Michelle Smith, Helen Ramsay, Alan Coulson, Christine Lloyd, Louise Clark, Sancha Martin, L M Beard, A. Tromans, Minna Lehväslaiho, Pamela Whittaker, Christopher M. Johnson, S. Y. Clark, David Beare, David Buck, Stephanie Lawlor, Charles A. Steward, Cari Soderlund, C. Clee, R. Connor, J. Lovell, Pawandeep Dhami, M. Leversha, K. F. Barlow, C. D. Skuce, Stephan Beck, D. R. Bentley, Stephen Ho, Catherine M. Rice, Darren Grafham, Benjamin Phillimore, P. W. Wray, Neil Sycamore, David Lloyd, George Stavrides, S. Austin Hammond, Jane Rogers, Alan Tracey, P. D. Heath, Julie Frankland, L J McConnachie, R. W. Plumb, Andrew Brown, John Wallis, Devesh Mistry, Anne Bridgeman, Kerstin Jekosch, O. Beasley, Carol Scott, James C. Mullikin, Audrey Fraser, Andrew King, J. P. Almeida, Amanda A. McMurray, Terri Pearce, S. Blakey, N P Carter, Rhian Gwilliam, K. Bates, Sarah Sims, M. M. Swann, Rebecca Deadman, S. R. Prathalingam, Duncan W. Thomas, C. Carder, Matt Dunn, V. Cobley, Karen Oliver, G.M.G. Clark, James Gilbert, Joanna Harley, Lucy Matthews, K. E. McLay, Jeffrey A. Bailey, M. Wall, Sarah Milne, Shirley Williams, Louise Tee, Ruth Taylor, Harminder Sehra, David J. Johnson, J. C. Chapman, Tim Hubbard, Chris Griffiths, Jane L. Holden, Jennifer Ashurst, Lucy Williams, Mark Griffiths, Anne Parker, W. Burrill, Lisa French, Gavin K. Laird, Anne Babbage, Elizabeth J. Huckle, Adrienne Hunt, Victoria Marsh, A. Thorpe, David L. Willey, C. L. Bagguley, M. Clamp, Panos Deloukas, P. Garner, A. M. Kimberley, Laurens Wilming, Andrew Ellington, A. I. Peck, Mike Kay, R. E. Hall

Abstract

The finished sequence of human chromosome 20 comprises 59,187,298 base pairs (bp) and represents 99.4% of the euchromatic DNA. A single contig of 26 megabases (Mb) spans the entire short arm, and five contigs separated by gaps totalling 320 kb span the long arm of this metacentric chromosome. An additional 234,339 bp of sequence has been determined within the pericentromeric region of the long arm. We annotated 727 genes and 168 pseudogenes in the sequence. About 64% of these genes have a 5' and a 3' untranslated region and a complete open reading frame. Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates, the mouse Mus musculus and the puffer fish Tetraodon nigroviridis, provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.

Citations Over TimeTop 1% of 2001 papers

Abstract

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