Genetic Variation in the Leptin Receptor Gene, Leptin, and Weight Gain in Young Dutch Adults
Obesity Research2003Vol. 11(3), pp. 377–386
Citations Over TimeTop 10% of 2003 papers
Caroline van Rossum, Barbara Hoebee, Marleen A. van Baak, Monica Mars, Wim H. M. Saris, Jacob C. Seidell
Abstract
Relatively high leptin levels predict weight gain, suggesting that leptin resistance plays a role in the development of obesity in the general population. Higher leptin levels for those with a Lys109Arg or Gln223Arg mutation (or a linked other marker) may imply that these subjects have a modified functional leptin receptor. However, the role of these mutations on weight gain is limited.
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