Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks
Scientific Reports2017Vol. 7(1), pp. 5664–5664
Citations Over TimeTop 12% of 2017 papers
Michael Ansorge, Jiranuwat Sapudom, Marina Chkolnikov, W.D. Martin, Ulf Anderegg, Stephanie Möller, Matthias Schnabelrauch, W. Pompe
Abstract
TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.
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