Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy
Chemical Communications2005Iss. 14, pp. 1860–1860
Citations Over TimeTop 16% of 2005 papers
Abstract
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
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