Colorimetric detection of UV light-induced single-strand DNA breaks using gold nanoparticles
The Analyst2012Vol. 138(3), pp. 783–786
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Abstract
We developed a colorimetric method to specifically detect single-strand DNA breaks using gold nanoparticles. In our assay, broken DNA cannot stabilize gold nanoparticles to prevent salt-induced aggregation as good as intact DNA can, and this effect can be easily observed with the naked eye as a red-to-purple color change.
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