Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents
Chemical Communications2012Vol. 48(12), pp. 1748–1748
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Pieter H. Bos, Alena Rudolph, Manuel Pérez, Martín Fañanás‐Mastral, Syuzanna R. Harutyunyan, Ben L. Feringa
Abstract
A highly efficient method is reported for the asymmetric ring opening of oxabicyclic alkenes with organolithium reagents. Using a copper/chiral phosphoramidite complex together with a Lewis acid (BF(3)·OEt(2)), full selectivity for the anti isomer and excellent enantioselectivities were obtained for the ring opened products.
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