Oligonucleotidecyclization: the thiol-maleimide reaction revisited
Chemical Communications2012Vol. 49(3), pp. 309–311
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Abstract
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels–Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.
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