Pyrazine-derived disulfide-reducing agent for chemical biology
Chemical Communications2014Vol. 50(67), pp. 9591–9591
Citations Over Time
Abstract
For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents.
Related Papers
- → [13] Reduction of disulfide bonds in proteins with dithiothreitol(1972)217 cited
- → Pyrazine-derived disulfide-reducing agent for chemical biology(2014)12 cited
- → Chemical Protection against X-irradiation by a New Reducing Agent 1,4-Dithiothreitol in Marsupial Leucocytes in Culture(1968)12 cited
- → Effect of Reducing Agents on the Solubilization of Renal Sodium and Potassium Dependent ATPase with Detergent1(1980)11 cited
- → ChemInform Abstract: A Reagent for Reduction of Disulfide Bonds in Proteins That Reduces Disulfide Bonds Faster Than Does Dithiothreitol.(1991)