Trisubstituted alkenes with a single activator as dipolarophiles in a highly diastereo- and enantioselective [3+2] cycloaddition with vinyl epoxides under Pd-catalysis
Chemical Communications2018Vol. 54(93), pp. 13143–13146
Citations Over TimeTop 10% of 2018 papers
Juan Du, Yang-Jie Jiang, Jiajia Suo, Wen‐Qiong Wu, Xiu‐Yan Liu, Di Chen, Chang‐Hua Ding, Yin Wei, Xue‐Long Hou
Abstract
1,1,2-Trisubstituted alkenes with a single strongly electronic withdrawing activator, which are unreactive electron-deficient alkenes in transition metal-catalyzed [3+2] cycloaddition with vinyl three-membered heterocycles, were used in the Pd-catalyzed asymmetric cycloaddition of vinyl epoxides, affording multifunctionalized tetrahydrofurans in high yields with high diastereo- and enantioselectivities.
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