Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2

Citations Over TimeTop 1% of 2020 papers

Abstract

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an unprecedented rate. In the present study, 4 marine sulfated polysaccharides were screened for their inhibitory activity against SARS-CoV-2, including sea cucumber sulfated polysaccharide (SCSP), fucoidan from brown algae, iota-carrageenan from red algae, and chondroitin sulfate C from sharks (CS). Of them, SCSP, fucoidan, and carrageenan showed significant antiviral activities at concentrations of 3.90-500 μg mL-1. SCSP exhibited the strongest inhibitory activity with IC50 of 9.10 μg mL-1. Furthermore, a test using pseudotype virus with S glycoprotein confirmed that SCSP could bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. The three antiviral polysaccharides could be employed to treat and prevent COVID-19.

Related Papers

• → Covid-19: What do we know about airborne transmission of SARS-CoV-2?(2021)23 cited
• → The Undiscovered Potential of Essential Oils for Treating SARS-CoV-2 (COVID-19)(2020)19 cited
• → Detection of SARS-CoV-2 through pool testing for COVID-19: an integrative review(2021)7 cited
• → Coronial cases: SARS-CoV-2 infection and Covid-19(2021)
• → Systematic Investigation of Selected Bio-molecules Potentially Effective in Inhibiting SARS-CoV-2/COVID-19 via In-Silico Analysis(2024)