Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
New England Journal of Medicine2016Vol. 374(19), pp. 1822–1830
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David A. Stempel, Ibrahim Raphiou, Kenneth M. Kral, Anne Yeakey, Amanda Emmett, Charlene M. Prazma, Kathleen S. Buaron, Steven Pascoe
Abstract
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group. (AUSTRI ClinicalTrials.gov number, NCT01475721.).
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