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Selected Sulfonyl Compounds as Anticancer/Antimalarial Agents
Australian Journal of Chemistry2003Vol. 56(11), pp. 1127–1133
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Richard Francis Langler, Robert L. Paddock, David B. Thompson, Ian Crandall, Michelle Ciach, Kevin C. Kain
Abstract
The synthesis and biological testing of a series of sulfonyl phenols and sulfonyl aryl methyl ethers has revealed that p -methoxyphenyl p -toluenesulfonate is a very selective and effective antimalarial agent which shows pronounced activity against human skin cancer cells. Application of a counter-attack strategy permits the direct preparation of the requisite tosylate ether from the bis(tosylate) of dihydroquinone.
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