Water-Assisted Organocatalysis: An Enantioselective Green Protocol for the Henry Reaction
Australian Journal of Chemistry2013Vol. 66(6), pp. 661–666
Citations Over TimeTop 20% of 2013 papers
Abstract
We report an enantioselective Henry (nitroaldol) reaction catalysed by an organocatalyst using water as solvent. The enantioselective synthesis of ß-nitroalcohols was achieved by using a neutral chiral organocatalyst, through strong hydrogen bonding, which results in the formation of corresponding products in excellent yield and enantioselectivity at room temperature. Other attractive features of the method are the eco-friendly, non-hazardous, and mild reaction conditions, inexpensive catalyst, and simple work up conditions.
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