Tenofovir‐Related Nephrotoxicity in Human Immunodeficiency Virus–Infected Patients: Three Cases of Renal Failure, Fanconi Syndrome, and Nephrogenic Diabetes Insipidus
Clinical Infectious Diseases2003Vol. 36(8), pp. 1070–1073
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Alexandre Karras, Matthieu Lafaurie, André Furco, A. Bourgarit, D Droz, D. Séréni, Christophe Legendre, Frank Martinez, Jean‐Michel Molina
Abstract
We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria).
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