Pharmacokinetics and Whole‐Blood Bactericidal Activity againstMycobacterium tuberculosisof Single Doses of PNU‐100480 in Healthy Volunteers
The Journal of Infectious Diseases2010Vol. 202(5), pp. 745–751
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Robert S. Wallis, Wesley Jakubiec, Vikas Kumar, Annette M. Silvia, Darcy Paige, Dessislava Dimitrova, Xiaoxi Li, Lynn Ladutko, Sheldon Campbell, Gerald Friedland, Mark J. Mitton‐Fry, Paul Miller
Abstract
Single doses of PNU-100480 to 1000 mg were well tolerated and exhibited antimycobacterial activity superior to 300 mg of linezolid at steady state. Additional studies are warranted to define its role in drug-resistant tuberculosis.
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