ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
Bioinformatics2009Vol. 25(8), pp. 1091–1093
Citations Over TimeTop 1% of 2009 papers
Gabriela Bindea, Bernhard Mlecnik, Hubert Hackl, Pornpimol Charoentong, Marie Tosolini, Amos Kirilovsky, Wolf H. Fridman, Franck Pagès, Zlatko Trajanoski, Jérôme Galon
Abstract
We have developed ClueGO, an easy to use Cytoscape plug-in that strongly improves biological interpretation of large lists of genes. ClueGO integrates Gene Ontology (GO) terms as well as KEGG/BioCarta pathways and creates a functionally organized GO/pathway term network. It can analyze one or compare two lists of genes and comprehensively visualizes functionally grouped terms. A one-click update option allows ClueGO to automatically download the most recent GO/KEGG release at any time. ClueGO provides an intuitive representation of the analysis results and can be optionally used in conjunction with the GOlorize plug-in.
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