Olfactory bulb neurogenesis depending on signaling in the subventricular zone
Citations Over TimeTop 15% of 2023 papers
Abstract
Olfaction is a crucial sense that is essential for the well-being and survival of individuals. Olfactory bulb (OB) is the first olfactory relay station, and its function depends on newly generated neurons from the subventricular zone (SVZ). These newly born neurons constantly migrate through the rostral migratory stream to integrate into existing neural networks within the OB, thereby contributing to olfactory information processing. However, the mechanisms underlying the contribution of SVZ adult neurogenesis to OB neurogenesis remain largely elusive. Adult neurogenesis is a finely regulated multistep process involving the proliferation of adult neural stem cells (aNSCs) and neural precursor cells, as well as the migration and differentiation of neuroblasts, and integration of newly generated neurons into preexisting neuronal circuitries. Recently, extensive studies have explored the mechanism of SVZ and OB neurogenesis. This review focused on elucidating various molecules and signaling pathways associated with OB neurogenesis dependent on the SVZ function. A better understanding of the mechanisms underlying the OB neurogenesis on the adult brain is an attractive prospect to induce aNSCs in SVZ to generate new neurons to ameliorate olfactory dysfunction that is involved in various diseases. It will also contribute to developing new strategies for the human aNSCs-based therapies.
Related Papers
- → Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension(2007)881 cited
- → Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain(2021)8 cited
- → Cell migration in the postnatal subventricular zone(2002)30 cited
- → Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis(2013)3 cited
- → Adult Neurogenesis in the Subventricular Zone(2019)1 cited