A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity
The Journals of Gerontology Series A2015Vol. 70(9), pp. 1097–1104
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Éric Ravussin, Leanne M. Redman, James Rochon, Sai Krupa Das, Luigi Fontana, William E. Kraus, Sergei Romashkan, Donald A. Williamson, Simin Nikbin Meydani, Dennis T. Villareal, Steven R. Smith, Richard I. Stein, Tammy Scott, Tiffany M. Stewart, Edward Saltzman, Samuel Klein, Manju Bhapkar, Corby K. Martin, Cheryl H. Gilhooly, John O. Holloszy, Evan C. Hadley, Susan B. Roberts, for the CALERIE Study Group
Abstract
Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies.
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