Anti-mutant efficacy of antibiotic combinations: in vitro model studies with linezolid and daptomycin
Journal of Antimicrobial Chemotherapy2021Vol. 76(7), pp. 1832–1839
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Stephen H. Zinner, Kamilla N. Alieva, Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Alexander A. Firsov
Abstract
The present study suggests that (i) the inhibition of S. aureus resistant mutants using linezolid/daptomycin combinations can be predicted by MPCs determined at pharmacokinetically derived antibiotic concentration ratios and (ii) T>MPC is a reliable predictor of the anti-mutant efficacy of antibiotic combinations as studied using in vitro dynamic models.
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