Correlation of CYP2C19 Phenotype With Voriconazole Plasma Concentration in Children
Journal of Pediatric Hematology/Oncology2013Vol. 35(5), pp. e219–e223
Citations Over TimeTop 10% of 2013 papers
Atsushi Narita, Hideki Muramatsu, Hirotoshi Sakaguchi, Sayoko Doisaki, Makito Tanaka, Asahito Hama, Akira Shimada, Yoshiyuki Takahashi, Nao Yoshida, Kimikazu Matsumoto, Koji Kato, Kazuko Kudo, Yoko Furukawa‐Hibi, Kiyofumi Yamada, Seiji Kojima
Abstract
The current study suggests that a significant association exists in children between the voriconazole plasma concentration and the CYP2C19 phenotype. Dose adjustment based on CYP2C19 phenotype may be useful during voriconazole therapy, especially for Japanese children, who as a group have a higher incidence of the poor metabolizer and intermediate metabolizer phenotypes.
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