The electromechanical window is no better than QT prolongation to assess risk of Torsade de Pointes in the complete atrioventricular block model in dogs
British Journal of Pharmacology2013Vol. 171(3), pp. 714–722
Citations Over TimeTop 16% of 2013 papers
Thom R.G. Stams, Vincent J.A. Bourgonje, Henriëtte D.M. Beekman, Marja Schoenmakers, Roel van der Nagel, Peter Oosterhoff, Jurren M. van Opstal, Marc A. Vos
Abstract
In the canine CAVB model, ventricular remodelling and I(Kr) block by dofetilide are associated with negative EMW values, but this reflects QT prolongation, and implies that the EMW lacks specificity to predict dofetilide-induced TdP.
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