Indoline‐3‐propionate and 3‐aminopropyl carbamates reduce lung injury and pro‐inflammatory cytokines induced in mice by LPS
British Journal of Pharmacology2014Vol. 172(4), pp. 1101–1113
Citations Over TimeTop 18% of 2014 papers
Abstract
Indoline carbamates are potent inhibitors of pro-inflammatory mediators in murine macrophages and in mice injected with LPS, acting via the p38 MAPK, AP-1 and NF-κB cascades. Indirect α-7nACh receptor activation by AN917, through inhibition of AChE, contributes to its anti-inflammatory effect. Indoline carbamates may have therapeutic potential for lung injury and other diseases associated with chronic inflammation without causing immunosuppression.
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