Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats
British Journal of Pharmacology2019Vol. 176(16), pp. 2922–2944
Citations Over TimeTop 10% of 2019 papers
Vincent Kam Wai Wong, Congling Qiu, Su Xu, Betty Yuen Kwan Law, Jianming Wu, Hui Wang, Francesco Michelangeli, Ivo Ricardo de Seabra Rodrigues Dias, Yuan Qu, Tsz Wai Chan, Yu Han, Ni Zhang, Simon Wing Fai Mok, Xi Chen, Lu Yu, Hudan Pan, Sami Hamdoun, Thomas Efferth, Wen Jing Yu, Wei Zhang, Zheng Li, Yuesheng Xie, Riqiang Luo, Quan Jiang, Liang Liu
Abstract
Celastrol triggered Ca2+ signalling to induce autophagic cell death in RASFs/RAFLS and ameliorated arthritis in AIA rats mediated by calcium-dependent/-binding proteins facilitating the exploitation of anti-arthritic drugs based on manipulation of Ca2+ signalling.
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