LUF7244, an allosteric modulator/activator of Kv11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model
British Journal of Pharmacology2019Vol. 176(19), pp. 3871–3885
Citations Over TimeTop 13% of 2019 papers
Muge Qile, Henriëtte D.M. Beekman, David J. Sprenkeler, Marien J. C. Houtman, Willem B. van Ham, Anna Stary‐Weinzinger, Stanislav Beyl, Steffen Hering, Dirk‐Jan van den Berg, Elizabeth C. M. de Lange, Laura H. Heitman, Adriaan P. IJzerman, Marc A. Vos, Marcel A. G. van der Heyden
Abstract
LUF7244 counteracted dofetilide-induced early afterdepolarizations in vitro and torsades de pointes in vivo. Allosteric modulators/activators of Kv 11.1 channels might neutralize adverse cardiac effects of existing drugs and newly developed compounds that display QTc lengthening.
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