A novel MAP3K7CL‐ERG fusion in a molecularly confirmed case of dermatofibrosarcoma protuberans with fibrosarcomatous transformation
Journal of Cutaneous Pathology2019Vol. 46(7), pp. 532–537
Citations Over TimeTop 10% of 2019 papers
Nolan Maloney, Julia A. Bridge, Francine De Abreu, Penelope Korkolopoulou, Stratigoula Sakellariou, Konstantinos Linos
Abstract
Dermatofibrosarcoma protuberans (DFSP) is a translocation-associated, low-grade sarcoma with fibroblastic differentiation. It is the most common superficial sarcoma, almost exclusively arising within the dermis. In a minority of cases, there is a transition from the conventional morphology to a fibrosarcomatous pattern, known as a fibrosarcomatous DFSP (FS-DFSP). Although a number of different molecular alterations have been described to account for this transformation, it remains poorly understood. Herein we report the first case of a FS-DFSP with a fusion between ERG, an ETS family transcription factor, and MAP3K7CL, a kinase gene rarely observed in fusion gene events.
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