Plasma and synovial fluid concentration of doxycycline following low‐dose, low‐frequency administration, and resultant inhibition of matrix metalloproteinase‐13 from interleukin‐stimulated equine synoviocytes
Equine Veterinary Journal2013Vol. 46(2), pp. 198–202
Citations Over TimeTop 23% of 2013 papers
Michael Maher, Lauren V. Schnabel, Jennifer Cross, Mark G. Papich, Thomas J. Divers, Lisa A. Fortier
Abstract
Low-dose orally administered doxycycline achieves SF concentrations in vivo capable of diminishing MMP-13 expression. This study supports the use of doxycycline as a disease modifying osteoarthritic drug.
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