Human skin fibrosis: up‐regulation of collagen type III gene transcription in the fibrotic skin nodules of lower limb lymphoedema
Tropical Medicine & International Health2019Vol. 25(3), pp. 319–327
Citations Over TimeTop 17% of 2019 papers
Arun Kumar Karayi, Vijaya Basavaraj, S. R. Narahari, Madhur Guruprasad Aggithaya, Terence J. Ryan, Rajendra Pilankatta
Abstract
Gene transcript analysis revealed significant up-regulation of Collagen type III vs. Collagen type I in fibrotic skin of limb nodules from patient biopsies. Histopathological and immunohistochemical analysis also revealed enhancement of Collagen types I and III in fibrotic vs. normal skin. The findings of this preliminary study indicate the potentially significant involvement of Collagen type III in the development of the fibrotic skin of grade-3 lymphoedema patients.
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