Resident lymphocytes in the dermis of the normal dorsolateral thoracic skin of alpacas
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Abstract
Background Small numbers of resident T lymphocytes are present in the dermis of normal skin of humans, cattle and sheep. Hypothesis/Objectives We wanted to determine the prevalence, numbers and immunophenotype of lymphocytes in the dermis of healthy skin from alpacas. Animals Skin biopsy specimens were collected from the dorsolateral thorax of 31 alpacas with normal skin. Methods Skin biopsy specimens were evaluated for the prevalence and numbers of CD 3+ and CD 79a+ lymphocytes. Results Resident CD 3+ and CD 79a+ lymphocytes were found around the superficial and deep dermal blood vessels. The CD 3+ lymphocytes were more numerous than CD 79a+ lymphocytes. Both CD 3+ and CD 79a+ lymphocytes were more numerous around superficial dermal blood vessels. Conclusions and clinical importance Resident CD 3+ and CD 79a+ lymphocytes are present around superficial and deep dermal blood vessels in normal skin from alpacas; hence, the presence of lymphocytes in these locations without obvious features of inflammation must be interpreted cautiously when evaluating skin biopsy specimens from alpacas with skin disease.
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