Influence of age on pulmonary diffusing capacity
Citations Over TimeTop 10% of 1959 papers
Abstract
The pulmonary function of 24 normal subjects ranging in age from 20 to 50 years has been studied at rest and during exercise. At rest there is a significant decrease with age in the pulmonary diffusing capacity and the level of diffusing capacity attained on exercise at any particular oxygen uptake decreases with increasing age. Simultaneous measurements of O 2 uptake, ventilation, end tidal O 2 and CO 2 concentration and calculated alveolar CO 2 concentration, using the Bohr equation, show no evidence that any of these measurements are significantly influenced by age. The predicted maximal O 2 diffusing capacity ( J. Appl. Physiol. 6: 588, 1954) predicts with fair accuracy the diffusing capacity for carbon monoxide that will be found in any given individual at an O2 uptake of about 2.8 l/min. It correctly predicts the change in CO diffusing capacity with increasing age. Reasons are given for suggesting that the decrease in pulmonary diffusing capacity observed may be explained by a diminution in cardiac output with increasing age. Submitted on November 21, 1958
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