Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer
Clinical Cancer Research2006Vol. 12(6), pp. 1883–1896
Citations Over TimeTop 13% of 2006 papers
Anjaiah Srirangam, Ranjana Mitra, Mu Wang, J. Christopher Gorski, Sunil Badve, LeeAnn Baldridge, Justin R. Hamilton, Hiromitsu Kishimoto, John W. Hawes, Lang Li, Christie M. Orschell, Edward F. Srour, Janice S. Blum, David B. Donner, George W. Sledge, Harikrishna Nakshatri, David A. Potter
Abstract
Ritonavir inhibits breast cancer growth in part by inhibiting Hsp90 substrates, including Akt. Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference.
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