Enhanced Expression of β3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase
Circulation2013Vol. 129(4), pp. 451–462
Citations Over TimeTop 10% of 2013 papers
Catharina Belge, Joanna Hammond, Emilie Dubois‐Deruy, Boris Manoury, Julien Hamelet, Christophe Beauloye, Andreas Markl, Anne–Catherine Pouleur, Luc Bertrand, Hrag Esfahani, Karima Jnaoui, Konrad R. Götz, Viacheslav O. Nikolaev, Annelies Vanderper, Paul Herijgers, Irina Lobysheva, Guido Iaccarino, Denise Hilfiker‐Kleiner, Geneviève Tavernier, Dominique Langin, Chantal Dessy, Jean‐Luc Balligand
Abstract
Cardiac-specific overexpression of β3-AR does not affect cardiac morphology at baseline but inhibits the hypertrophic response to neurohormonal stimulation in vivo and in vitro, through a NOS-mediated mechanism. Activation of the cardiac β3-AR pathway may provide future therapeutic avenues for the modulation of hypertrophic remodeling.
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