Vascular Endothelial Growth Factor Expression and Signaling in the Lens
Investigative Ophthalmology & Visual Science2003Vol. 44(9), pp. 3911–3911
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Ying‐Bo Shui, Xiaohui Wang, Joan S. Hu, Shuiping Wang, Claudia M. Garcia, Jay D. Potts, Yogendra Sharma, David C. Beebe
Abstract
VEGF-A secreted by lens cells may stimulate the formation of the fetal vasculature, but regression of these vessels is not likely to be caused by a reduction in VEGF-A production by the lens. An active VEGF-A signaling system of unknown function appears to be active in the lens. It is likely that VEGF-A expression is regulated by tissue hypoxia at all stages of lens development.
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